Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy
Selective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy through its mitochondrial targeting and interaction with tumor n...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2018-05-01
|
| Series: | Molecular & Cellular Oncology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/23723556.2017.1327005 |
| _version_ | 1797677175690756096 |
|---|---|
| author | Mengjie Hu Gulimiran Alitongbieke Ying Su Hu Zhou Xiao-kun Zhang |
| author_facet | Mengjie Hu Gulimiran Alitongbieke Ying Su Hu Zhou Xiao-kun Zhang |
| author_sort | Mengjie Hu |
| collection | DOAJ |
| description | Selective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy through its mitochondrial targeting and interaction with tumor necrosis factor receptor-associated factor 2 (TRAF2) and the autophagic adaptor p62/SQSTM1. |
| first_indexed | 2024-03-11T22:41:15Z |
| format | Article |
| id | doaj.art-dd28b9f0d0554d88a8a829a27dc6473e |
| institution | Directory Open Access Journal |
| issn | 2372-3556 |
| language | English |
| last_indexed | 2024-03-11T22:41:15Z |
| publishDate | 2018-05-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Molecular & Cellular Oncology |
| spelling | doaj.art-dd28b9f0d0554d88a8a829a27dc6473e2023-09-22T09:10:58ZengTaylor & Francis GroupMolecular & Cellular Oncology2372-35562018-05-015310.1080/23723556.2017.13270051327005Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagyMengjie Hu0Gulimiran Alitongbieke1Ying Su2Hu Zhou3Xiao-kun Zhang4Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen UniversityFujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen UniversityFujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen UniversityFujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen UniversityFujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen UniversitySelective clearance of damaged mitochondria can reverse pathological status in chronic inflammatory diseases. We recently identified a critical role of nuclear receptor Nur77 and celastrol in priming inflamed mitochondria for autophagy through its mitochondrial targeting and interaction with tumor necrosis factor receptor-associated factor 2 (TRAF2) and the autophagic adaptor p62/SQSTM1.http://dx.doi.org/10.1080/23723556.2017.1327005autophagycelastrolmitochondriamitophagynur77p62/sqstm1traf2 |
| spellingShingle | Mengjie Hu Gulimiran Alitongbieke Ying Su Hu Zhou Xiao-kun Zhang Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy Molecular & Cellular Oncology autophagy celastrol mitochondria mitophagy nur77 p62/sqstm1 traf2 |
| title | Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy |
| title_full | Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy |
| title_fullStr | Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy |
| title_full_unstemmed | Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy |
| title_short | Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy |
| title_sort | moving nuclear receptor nur77 to damaged mitochondria for clearance by mitophagy |
| topic | autophagy celastrol mitochondria mitophagy nur77 p62/sqstm1 traf2 |
| url | http://dx.doi.org/10.1080/23723556.2017.1327005 |
| work_keys_str_mv | AT mengjiehu movingnuclearreceptornur77todamagedmitochondriaforclearancebymitophagy AT gulimiranalitongbieke movingnuclearreceptornur77todamagedmitochondriaforclearancebymitophagy AT yingsu movingnuclearreceptornur77todamagedmitochondriaforclearancebymitophagy AT huzhou movingnuclearreceptornur77todamagedmitochondriaforclearancebymitophagy AT xiaokunzhang movingnuclearreceptornur77todamagedmitochondriaforclearancebymitophagy |