Targeting pancreatic cancer with combinatorial treatment of CPI-613 and inhibitors of lactate metabolism.

Targeting pancreatic cancer with combinatorial treatment of CPI-613 and inhibitors of lactate metabolism.

Pancreatic cancer is the fourth leading cause of cancer death, with a 5-year survival rate of 10%. A stagnant high mortality rate over the last decades highlights the need for innovative therapeutic approaches. Pancreatic tumors pursue an altered metabolism in order to maintain energy generation und...

Full description

Bibliographic Details
Main Authors: Simone Kumstel, Tim Schreiber, Lea Goldstein, Jan Stenzel, Tobias Lindner, Markus Joksch, Xianbin Zhang, Edgar Heinz Uwe Wendt, Maria Schönrogge, Bernd Krause, Brigitte Vollmar, Dietmar Zechner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0266601

Internet

https://doi.org/10.1371/journal.pone.0266601

Similar Items