Scylla and Charybdis: Unpalatable choices in managing hypodiploid acute lymphoblastic leukemia

Scylla and Charybdis: Unpalatable choices in managing hypodiploid acute lymphoblastic leukemia

Acquired TP53 alterations are present in > 90% of cases of paediatric low-hypodiploid acute lymphoblastic leukaemia (ALL), and ≈ 50% of patients with this subtype harbor germline pathogenic / likely pathogenic (P/LP) TP53 alterations. Despite dose intensified, conventional chemotherapy, survival...

Full description

Bibliographic Details
Main Authors: John N. Colgan, Noemi A. Fuentes-Bolanos, Draga Barbaric, Luciano Dalla-Pozza, Richard Mitchell, Sujith Samarasinghe, Martin Schrappe, Katherine M. Tucker, Kjeld Schmiegelow, Toby N. Trahair
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:EJC Paediatric Oncology
Subjects:
Hypodiploid
Low-Hypodiploid
Precursor-B acute lymphoblastic leukaemia (B-ALL)
Li-fraumeni syndrome
Immunotherapy
Haematopoietic stem cell transplantation
Online Access:http://www.sciencedirect.com/science/article/pii/S2772610X23001319

Internet

http://www.sciencedirect.com/science/article/pii/S2772610X23001319

Similar Items