Pyridoxamine and Aminoguanidine Attenuate the Abnormal Aggregation of β-Tubulin and Suppression of Neurite Outgrowth by Glyceraldehyde-Derived Toxic Advanced Glycation End-Products

Pyridoxamine and Aminoguanidine Attenuate the Abnormal Aggregation of β-Tubulin and Suppression of Neurite Outgrowth by Glyceraldehyde-Derived Toxic Advanced Glycation End-Products

Diabetes mellitus (DM) has been identified as a risk factor for the onset and progression of Alzheimer’s disease (AD). In our previous study, we demonstrated that glyceraldehyde (GA)-derived toxic advanced glycation end-products (toxic AGEs, TAGE) induced similar alterations to those observed in AD....

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Bibliographic Details
Main Authors: Hayahide Ooi, Ryuto Nasu, Ayako Furukawa, Masayoshi Takeuchi, Yoshiki Koriyama
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Pharmacology
Subjects:
Alzheimer’s
diabetes mellitus
glyceraldehyde
advanced glycation end-products
β-tubulin
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.921611/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.921611/full

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