A probabilistic framework for cellular lineage reconstruction using integrated single-cell 5-hydroxymethylcytosine and genomic DNA sequencing

A probabilistic framework for cellular lineage reconstruction using integrated single-cell 5-hydroxymethylcytosine and genomic DNA sequencing

Summary: Lineage reconstruction is central to understanding tissue development and maintenance. To overcome the limitations of current techniques that typically reconstruct clonal trees using genetically encoded reporters, we report scPECLR, a probabilistic algorithm to endogenously infer lineage tr...

Full description

Bibliographic Details
Main Authors: Chatarin Wangsanuwat, Alex Chialastri, Javier F. Aldeguer, Nicolas C. Rivron, Siddharth S. Dey
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Cell Reports: Methods
Subjects:
lineage reconstruction
individual-cell-division resolution
5-hydroxymethylcytosine
integrated single-cell genomic DNA and 5-hydroxymethylcytosine sequencing
preimplantation mouse embryogenesis
immortal strand hypothesis
Online Access:http://www.sciencedirect.com/science/article/pii/S2667237521001089

Internet

http://www.sciencedirect.com/science/article/pii/S2667237521001089

Similar Items