Nlrp12 deficiency alters gut microbiota and ameliorates Faslpr-mediated systemic autoimmunity in male mice

Nlrp12 deficiency alters gut microbiota and ameliorates Faslpr-mediated systemic autoimmunity in male mice

NLRP12 has dual roles in shaping inflammation. We hypothesized that NLRP12 would modulate myeloid cells and T cell function to control systemic autoimmunity. Contrary to our hypothesis, the deficiency of Nlrp12 in autoimmune-prone B6.Faslpr/lpr mice ameliorated autoimmunity in males but not females....

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Bibliographic Details
Main Authors: Leila Abdelhamid, Jiangdi Mao, Xavier Cabana-Puig, Jing Zhu, Brianna K. Swartwout, Michael R. Edwards, James C. Testerman, Jacquelyn S. Michaelis, Irving Coy Allen, S. Ansar Ahmed, Xin M. Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
NLRP12
gut microbiota
autoimmunity
sex dependence
pathogenic T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1120958/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1120958/full

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