Clinical application of prion-like seeding in α-synucleinopathies: Early and non-invasive diagnosis and therapeutic development

Clinical application of prion-like seeding in α-synucleinopathies: Early and non-invasive diagnosis and therapeutic development

The accumulation and deposition of misfolded α-synuclein (α-Syn) aggregates in the brain is the central event in the pathogenesis of α-synucleinopathies, including Parkinson’s disease, dementia with Lewy bodies, and multiple-system atrophy. Currently, the diagnosis of these diseases mainly relies on...

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Bibliographic Details
Main Authors: Jiaqi Li, Haiyang Luo, Honglin Zheng, Suying Duan, Taiqi Zhao, Yanpeng Yuan, Yutao Liu, Xiaoyun Zhang, Yangyang Wang, Jing Yang, Yuming Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
α-synuclein
RT-QuIC
prion
Parkinson’s disease
multiple-system atrophy
dementia with Lewy bodies
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.975619/full

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https://www.frontiersin.org/articles/10.3389/fnmol.2022.975619/full

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