Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions
LRRTM1 is a post synaptic adhesion protein, that promotes AMPA receptor mediated synaptic transmission. Here the authors show that LRRTM1 and the adhesion molecule SynCAM 1 act together to organize synapses in the prefrontal cortex with relevance for cognitive function in mice.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36042-w |
| _version_ | 1811175779408543744 |
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| author | Karen Perez de Arce Adema Ribic Dhrubajyoti Chowdhury Katherine Watters Garth J. Thompson Basavaraju G. Sanganahalli Elizabeth T. C. Lippard Astrid Rohlmann Stephen M. Strittmatter Markus Missler Fahmeed Hyder Thomas Biederer |
| author_facet | Karen Perez de Arce Adema Ribic Dhrubajyoti Chowdhury Katherine Watters Garth J. Thompson Basavaraju G. Sanganahalli Elizabeth T. C. Lippard Astrid Rohlmann Stephen M. Strittmatter Markus Missler Fahmeed Hyder Thomas Biederer |
| author_sort | Karen Perez de Arce |
| collection | DOAJ |
| description | LRRTM1 is a post synaptic adhesion protein, that promotes AMPA receptor mediated synaptic transmission. Here the authors show that LRRTM1 and the adhesion molecule SynCAM 1 act together to organize synapses in the prefrontal cortex with relevance for cognitive function in mice. |
| first_indexed | 2024-04-10T19:42:30Z |
| format | Article |
| id | doaj.art-dd39d5faa5084166b39c89b441a273e5 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-10T19:42:30Z |
| publishDate | 2023-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-dd39d5faa5084166b39c89b441a273e52023-01-29T12:17:15ZengNature PortfolioNature Communications2041-17232023-01-0114111810.1038/s41467-023-36042-wConcerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functionsKaren Perez de Arce0Adema Ribic1Dhrubajyoti Chowdhury2Katherine Watters3Garth J. Thompson4Basavaraju G. Sanganahalli5Elizabeth T. C. Lippard6Astrid Rohlmann7Stephen M. Strittmatter8Markus Missler9Fahmeed Hyder10Thomas Biederer11Department of Neuroscience, Tufts University School of MedicineDepartment of Neuroscience, Tufts University School of MedicineDepartment of Neurology, Yale School of MedicineDepartment of Neuroscience, Tufts University School of MedicineDepartment of Radiology and Biomedical Imaging, Yale School of MedicineDepartment of Radiology and Biomedical Imaging, Yale School of MedicineDepartment of Radiology and Biomedical Imaging, Yale School of MedicineInstitute of Anatomy and Molecular Neurobiology, Westfälische Wilhelms-UniversityDepartment of Neurology, Yale School of MedicineInstitute of Anatomy and Molecular Neurobiology, Westfälische Wilhelms-UniversityDepartment of Radiology and Biomedical Imaging, Yale School of MedicineDepartment of Neuroscience, Tufts University School of MedicineLRRTM1 is a post synaptic adhesion protein, that promotes AMPA receptor mediated synaptic transmission. Here the authors show that LRRTM1 and the adhesion molecule SynCAM 1 act together to organize synapses in the prefrontal cortex with relevance for cognitive function in mice.https://doi.org/10.1038/s41467-023-36042-w |
| spellingShingle | Karen Perez de Arce Adema Ribic Dhrubajyoti Chowdhury Katherine Watters Garth J. Thompson Basavaraju G. Sanganahalli Elizabeth T. C. Lippard Astrid Rohlmann Stephen M. Strittmatter Markus Missler Fahmeed Hyder Thomas Biederer Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions Nature Communications |
| title | Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions |
| title_full | Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions |
| title_fullStr | Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions |
| title_full_unstemmed | Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions |
| title_short | Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions |
| title_sort | concerted roles of lrrtm1 and syncam 1 in organizing prefrontal cortex synapses and cognitive functions |
| url | https://doi.org/10.1038/s41467-023-36042-w |
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