Improved Characteristics of RANKL Immuno-PET Imaging Using Radiolabeled Antibody Fab Fragments

Improved Characteristics of RANKL Immuno-PET Imaging Using Radiolabeled Antibody Fab Fragments

Purpose: RANKL expression in the tumor microenvironment has been identified as a biomarker of immune suppression, negating the effect of some cancer immunotherapies. Previously we had developed a radiotracer based on the FDA-approved RANKL-specific antibody denosumab, [<sup>89</sup>Zr]Zr...

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Bibliographic Details
Main Authors: Jonatan Dewulf, Ivanna Hrynchak, Sarah Geudens, Isabel Pintelon, Christel Vangestel, José Sereno, Peter A. van Dam, Antero J. Abrunhosa, Filipe Elvas, Tim Van den Wyngaert
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pharmaceutics
Subjects:
RANKL
antibody
Fab fragment
tumor imaging
immuno-PET
Online Access:https://www.mdpi.com/1999-4923/14/5/939

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https://www.mdpi.com/1999-4923/14/5/939

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