Enzymatic and Molecular Characterization of Anti-<i>Leishmania</i> Molecules That Differently Target <i>Leishmania</i> and Mammalian eIF4A Proteins, LieIF4A and eIF4A<sub>Mus</sub>

Enzymatic and Molecular Characterization of Anti-<i>Leishmania</i> Molecules That Differently Target <i>Leishmania</i> and Mammalian eIF4A Proteins, LieIF4A and eIF4A<sub>Mus</sub>

Previous investigations of the <i>Leishmania infantum</i> eIF4A-like protein (LieIF4A) as a potential drug target delivered cholestanol derivatives inhibitors. Here, we investigated the mode of action of cholesterol derivatives as a novel scaffold structure of LieIF4A inhibitors on the R...

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Bibliographic Details
Main Authors: Yosser Zina Abdelkrim, Emna Harigua-Souiai, Imen Bassoumi-Jamoussi, Mourad Barhoumi, Josette Banroques, Khadija Essafi-Benkhadir, Michael Nilges, Arnaud Blondel, N. Kyle Tanner, Ikram Guizani
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Molecules
Subjects:
7-α-aminocholesterol
drug design
translation-initiation factor
inhibitor
<i>Leishmania infantum</i>
Online Access:https://www.mdpi.com/1420-3049/27/18/5890

Internet

https://www.mdpi.com/1420-3049/27/18/5890

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