Powerful eQTL mapping through low-coverage RNA sequencing

Powerful eQTL mapping through low-coverage RNA sequencing

Summary: Mapping genetic variants that regulate gene expression (eQTL mapping) in large-scale RNA sequencing (RNA-seq) studies is often employed to understand functional consequences of regulatory variants. However, the high cost of RNA-seq limits sample size, sequencing depth, and, therefore, disco...

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Bibliographic Details
Main Authors: Tommer Schwarz, Toni Boltz, Kangcheng Hou, Merel Bot, Chenda Duan, Loes Olde Loohuis, Marco P. Boks, René S. Kahn, Roel A. Ophoff, Bogdan Pasaniuc
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:HGG Advances
Subjects:
RNA-seq
eQTL mapping
association testing
low coverage
Online Access:http://www.sciencedirect.com/science/article/pii/S2666247722000197

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http://www.sciencedirect.com/science/article/pii/S2666247722000197

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