A pilot investigation of differential hydroxymethylation levels in patient-derived neural stem cells implicates altered cortical development in bipolar disorder

A pilot investigation of differential hydroxymethylation levels in patient-derived neural stem cells implicates altered cortical development in bipolar disorder

IntroductionBipolar disorder (BD) is a chronic mental illness characterized by recurrent episodes of mania and depression and associated with social and cognitive disturbances. Environmental factors, such as maternal smoking and childhood trauma, are believed to modulate risk genotypes and contribut...

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Bibliographic Details
Main Authors: Ashish Kumar, Mark Z. Kos, Donna Roybal, Melanie A. Carless
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Psychiatry
Subjects:
hydroxymethylation
bipolar disorder
neuronal differentiation
RRHP
reduced representation 5-hydroxymethylcytosine profiling
neural stem cell (NSC)
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1077415/full

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https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1077415/full

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