A pilot investigation of differential hydroxymethylation levels in patient-derived neural stem cells implicates altered cortical development in bipolar disorder

A pilot investigation of differential hydroxymethylation levels in patient-derived neural stem cells implicates altered cortical development in bipolar disorder

IntroductionBipolar disorder (BD) is a chronic mental illness characterized by recurrent episodes of mania and depression and associated with social and cognitive disturbances. Environmental factors, such as maternal smoking and childhood trauma, are believed to modulate risk genotypes and contribut...

Full description

Bibliographic Details
Main Authors:	Ashish Kumar, Mark Z. Kos, Donna Roybal, Melanie A. Carless
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-04-01
Series:	Frontiers in Psychiatry
Subjects:	hydroxymethylation bipolar disorder neuronal differentiation RRHP reduced representation 5-hydroxymethylcytosine profiling neural stem cell (NSC)
Online Access:	https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1077415/full

Similar Items

Aerobic exercise alters DNA hydroxymethylation levels in an experimental rodent model of temporal lobe epilepsy
by: Silvienne C. Sint Jago, et al.
Published: (2024-01-01)

Synthesis of N-(hydroxymethylene)thioamides by N-hydroxymethylation of 2-cyanothioacrylamides
by: Arina G. Levchenko, et al.
Published: (2021-11-01)

Reduced metal nanocatalysts for selective electrochemical hydrogenation of biomass-derived 5-(hydroxymethyl)furfural to 2,5-bis(hydroxymethyl)furan in ambient conditions
by: Baleeswaraiah Muchharla, et al.
Published: (2023-06-01)

Genome-wide characterization of cytosine-specific 5-hydroxymethylation in normal breast tissue
by: Owen M. Wilkins, et al.
Published: (2020-04-01)

Sulfonation of Hydroxymethylated Lignin and Its Application
by: Weijue Gao, et al.
Published: (2019-05-01)

Transition of allele-specific DNA hydroxymethylation at regulatory loci is associated with phenotypic variation in monozygotic twins discordant for psychiatric disorders
by: Junping Ye, et al.
Published: (2023-12-01)

Alterations in DNA 5-hydroxymethylation patterns in the hippocampus of an experimental model of chronic epilepsy
by: Rudhab Bahabry, et al.
Published: (2024-10-01)

Non-alcoholic fatty liver disease (NAFLD) is associated with dynamic changes in DNA hydroxymethylation
by: Marcus J. Lyall, et al.
Published: (2020-02-01)

Methods for Detection and Mapping of Methylated and Hydroxymethylated Cytosine in DNA
by: Olga Kisil, et al.
Published: (2024-10-01)

Binderless MDF from Hydroxymethylated Kenaf Pulp
by: Nyoman J Wistara, et al.
Published: (2018-01-01)

Aberrantly hydroxymethylated differentially expressed genes and the associated protein pathways in osteoarthritis
by: Yang Fang, et al.
Published: (2019-02-01)

Research progress on roles and mechanisms of DNA hydroxymethylation in health effects induced by arsenic exposure
by: Jingjing WU, et al.
Published: (2024-03-01)

Carboligation of 5-(hydroxymethyl)furfural via whole-cell catalysis to form C12 furan derivatives and their use for hydrazone formation
by: Sara Jonsdottir Glaser, et al.
Published: (2023-06-01)

Morphology of the rat knee joint after intraarticular injection of hydroxymethyl-quinoxaline dioxide
by: A.V. Degtiar
Published: (2022-09-01)

A method for identifying allele-specific hydroxymethylation
by: Yoichi Yamada, et al.
Published: (2020-03-01)

Age-related epigenome-wide DNA methylation and hydroxymethylation in longitudinal mouse blood
by: Joseph Kochmanski, et al.
Published: (2018-07-01)

Prenatal 1‐Nitropyrene Exposure Causes Autism‐Like Behavior Partially by Altering DNA Hydroxymethylation in Developing Brain
by: Ting Zhao, et al.
Published: (2024-07-01)

The role of DNA hydroxymethylation and TET enzymes in placental development and pregnancy outcome
by: Sara Vasconcelos, et al.
Published: (2023-04-01)

Developmental changes and sex differences in DNA methylation and demethylation in hypothalamic regions of the mouse brain
by: Carla D. Cisternas, et al.
Published: (2020-02-01)

Hydroxymethyl furfural (HMF) a high strength cellulose resin for wood composite laminates
by: Vinutha Moses, et al.
Published: (2022-12-01)

Cannabichromene Induces Neuronal Differentiation in NSC-34 Cells: Insights from Transcriptomic Analysis
by: Andrea Valeri, et al.
Published: (2023-03-01)

Prenatal lead (Pb) exposure is associated with differential placental DNA methylation and hydroxymethylation in a human population
by: Pei Wen Tung, et al.
Published: (2022-12-01)

Developmental exposures to common environmental contaminants, DEHP and lead, alter adult brain and blood hydroxymethylation in mice
by: Rebekah L. Petroff, et al.
Published: (2023-06-01)

Decreased global DNA hydroxymethylation in neural tube defects: Association with polycyclic aromatic hydrocarbons
by: Yun Huang, et al.
Published: (2019-10-01)

Exploring the Epigenetic Landscape of Spermatozoa: Impact of Oxidative Stress and Antioxidant Supplementation on DNA Methylation and Hydroxymethylation
by: Elisa Hug, et al.
Published: (2024-12-01)

Associations of NPPA promoter true methylation and hydroxymethylation with ischemic stroke and its functional outcome
by: Jialing Yao, et al.
Published: (2024-11-01)

DNA hydroxymethylation increases the susceptibility of reactivation of methylated P16 alleles in cancer cells
by: Paiyun Li, et al.
Published: (2020-07-01)

Association of 5-hydroxymethylation and 5-methylation of DNA cytosine with tissue-specific gene expression
by: V. K. Chaithanya Ponnaluri, et al.
Published: (2017-02-01)

DNA hydroxymethylation differences underlie phenotypic divergence of somatic growth in Nile tilapia reared in common garden
by: Ioannis Konstantinidis, et al.
Published: (2023-12-01)

The chromatin remodelling protein LSH/HELLS regulates the amount and distribution of DNA hydroxymethylation in the genome
by: Maud De Dieuleveult, et al.
Published: (2022-04-01)

Analysis of genome-wide 5-hydroxymethylation of blood samples stored in different anticoagulants: opportunities for the expansion of clinical resources for epigenetic research
by: Lu Gao, et al.
Published: (2023-12-01)

Sulfinate Based Selective Labeling of 5‑Hydroxymethylcytosine: Application to Biotin Pull Down Assay
by: Wu, Qiong, et al.
Published: (2018)

Induction of Radiata Pine Somatic Embryogenesis at High Temperatures Provokes a Long-Term Decrease in DNA Methylation/Hydroxymethylation and Differential Expression of Stress-Related Genes
by: Ander Castander-Olarieta, et al.
Published: (2020-12-01)

Hypomethylation of LINE-1 repeat elements and global loss of DNA hydroxymethylation in vapers and smokers
by: Andrew W. Caliri, et al.
Published: (2020-08-01)

Hydroxymethylation hydroxylation of 1,3-diarylpropene through a catalytic diastereoselective Prins reaction: cyclization logic and access to brazilin core
by: Xin-Ting Hu, et al.
Published: (2024-05-01)

Protective effect of vitamin C against tetrachlorobenzoquinone-induced 5-hydroxymethylation-dependent apoptosis in HepG2 cells mainly via the mitochondrial apoptosis pathway
by: Cuiping Li, et al.
Published: (2023-07-01)

Ascorbic Acid Promotes Functional Restoration after Spinal Cord Injury Partly by Epigenetic Modulation
by: Jin Young Hong, et al.
Published: (2020-05-01)

Aberrant hydroxymethylation of ANGPTL4 is associated with selective intrauterine growth restriction in monochorionic twin pregnancies
by: Yi Zhang, et al.
Published: (2020-08-01)

Recent advances in the catalytic production of bio-based diol 2,5-bis(hydroxymethyl)furan
by: Wenguang Zhao, et al.
Published: (2023-06-01)

Unidirectional alteration of methylation and hydroxymethylation at the promoters and differential gene expression in oral squamous cell carcinoma
by: Weizhi Zhao, et al.
Published: (2023-10-01)