Mitochondrial Ndufa4l2 Enhances Deposition of Lipids and Expression of Ca9 in the TRACK Model of Early Clear Cell Renal Cell Carcinoma

Mitochondrial Ndufa4l2 Enhances Deposition of Lipids and Expression of Ca9 in the TRACK Model of Early Clear Cell Renal Cell Carcinoma

Mitochondrial dysfunction and aberrant glycolysis are hallmarks of human clear cell renal cell carcinoma (ccRCC). Whereas glycolysis is thoroughly studied, little is known about the mitochondrial contribution to the pathology of ccRCC. Mitochondrial Ndufa4l2 is predictive of poor survival of ccRCC p...

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Bibliographic Details
Main Authors: Kristian B. Laursen, Qiuying Chen, Francesca Khani, Nabeel Attarwala, Steve S. Gross, Lukas Dow, David M. Nanus, Lorraine J. Gudas
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Oncology
Subjects:
clear cell renal cell carcinoma
hypoxia
HIF1
von Hippel-Lindau
proximal tubules
lipids
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.783856/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2021.783856/full

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