A ubiquitous bone marrow reservoir of preexisting SARS-CoV-2-reactive memory CD4+ T lymphocytes in unexposed individuals

A ubiquitous bone marrow reservoir of preexisting SARS-CoV-2-reactive memory CD4+ T lymphocytes in unexposed individuals

Circulating, blood-borne SARS-CoV-2-reactive memory T cells in persons so far unexposed to SARS-CoV-2 or the vaccines have been described in 20-100% of the adult population. They are credited with determining the efficacy of the immune response in COVID-19. Here, we demonstrate the presence of preex...

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Bibliographic Details
Main Authors: Jinchan Li, Simon Reinke, Yu Shen, Lena Schollmeyer, Yuk-Chien Liu, Zixu Wang, Sebastian Hardt, Christian Hipfl, Ute Hoffmann, Stefan Frischbutter, Hyun-Dong Chang, Tobias Alexander, Carsten Perka, Helena Radbruch, Zhihai Qin, Andreas Radbruch, Jun Dong
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
SARS-CoV-2
cross-reactive
memory CD4+ T lymphocytes
human bone marrow
peripheral blood
polyfunctional
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1004656/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1004656/full

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