A ubiquitous bone marrow reservoir of preexisting SARS-CoV-2-reactive memory CD4+ T lymphocytes in unexposed individuals
Circulating, blood-borne SARS-CoV-2-reactive memory T cells in persons so far unexposed to SARS-CoV-2 or the vaccines have been described in 20-100% of the adult population. They are credited with determining the efficacy of the immune response in COVID-19. Here, we demonstrate the presence of preex...
Main Authors: | Jinchan Li, Simon Reinke, Yu Shen, Lena Schollmeyer, Yuk-Chien Liu, Zixu Wang, Sebastian Hardt, Christian Hipfl, Ute Hoffmann, Stefan Frischbutter, Hyun-Dong Chang, Tobias Alexander, Carsten Perka, Helena Radbruch, Zhihai Qin, Andreas Radbruch, Jun Dong |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2022-10-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.1004656/full |
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