Glycyrrhizin Attenuates Carcinogenesis by Inhibiting the Inflammatory Response in a Murine Model of Colorectal Cancer

Glycyrrhizin Attenuates Carcinogenesis by Inhibiting the Inflammatory Response in a Murine Model of Colorectal Cancer

Glycyrrhizin (GL), an important active ingredient of licorice root, which weakens the proinflammatory effects of high-mobility group box 1 (HMGB1) by blocking HMGB1 signaling. In this study, we investigated whether GL could suppress inflammation and carcinogenesis in an azoxymethane (AOM)/dextran so...

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Bibliographic Details
Main Authors: Guifeng Wang, Keiichi Hiramoto, Ning Ma, Nobuji Yoshikawa, Shiho Ohnishi, Mariko Murata, Shosuke Kawanishi
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
colon cancer
Glycyrrhizin
COX-2
HMGB1
8-NitroG
8-OxodG
Online Access:https://www.mdpi.com/1422-0067/22/5/2609

Internet

https://www.mdpi.com/1422-0067/22/5/2609

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