STC3141 improves acute lung injury through neutralizing circulating histone in rat with experimentally-induced acute respiratory distress syndrome

STC3141 improves acute lung injury through neutralizing circulating histone in rat with experimentally-induced acute respiratory distress syndrome

Background: Acute respiratory distress syndrome (ARDS) remains a challenge because of its high morbidity and mortality. Circulation histones levels in ARDS patients were correlated to disease severity and mortality. This study examined the impact of histone neutralization in a rat model of acute lun...

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Bibliographic Details
Main Authors: Yangyang Ge, Chenchen Wang, Chenye Yao, Yong Wang, Yuduo Zheng, Junjie Luo, Jiayi Chen, Yu Wang, Fuquan Wang, Li Wang, Yun Lin, Lin Shi, Shanglong Yao
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Pharmacology
Subjects:
ARDS
ALI
histone
STC3141
histone neutralization
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1166814/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1166814/full

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