Persistent pain induces mood problems and memory loss by the involvement of cytokines, growth factors, and supraspinal glial cells

Persistent pain induces mood problems and memory loss by the involvement of cytokines, growth factors, and supraspinal glial cells

Lesions of peripheral nerves lead to pain, hyperalgesia, and psychological comorbidities. However, the relationship between mood disorders and neuropathic pain is unclear, as well as the underlying mechanisms related to these disorders. Therefore, we investigated if nerve injury induces depression,...

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Bibliographic Details
Main Authors: Morgana D. da Silva, PhD, Giselle Guginski, PhD, Karina L. Sato, PhD, Luciana Sayuri Sanada, PhD, Kathleen A. Sluka, PhD, Adair R.S. Santos, PhD
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Neuropathic pain
Mood disorders
Inflammatory cytokines
Neurotrophic factors
Glial activation
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354620300831

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http://www.sciencedirect.com/science/article/pii/S2666354620300831

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