Alterations of the miR-126-3p/POU2AF1/Spi-B Axis and JCPyV Reactivation in Multiple Sclerosis Patients Receiving Natalizumab

Alterations of the miR-126-3p/POU2AF1/Spi-B Axis and JCPyV Reactivation in Multiple Sclerosis Patients Receiving Natalizumab

Natalizumab (NTZ) can reactivate human polyomavirus John Cunningham polyomavirus (JCPyV) latent infection and lead to progressive multifocal leukoencephalopathy (PML). NTZ modulates the expression of microRNA-126-3p (miR-126-3p) and its target genes, Spi-B, POU2AF1, and vascular cell adhesion molecu...

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Bibliographic Details
Main Authors: Roberta Mancuso, Simone Agostini, Ambra Hernis, Domenico Caputo, Daniela Galimberti, Elio Scarpini, Mario Clerici
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Neurology
Subjects:
circulating microRNA (miRNA)
natalizumab (Tysabri®)
JCPyV
multiple sclerosis
rehabilitation
progressive multifocal leukoencephalopathy (PML)
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2022.819911/full

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https://www.frontiersin.org/articles/10.3389/fneur.2022.819911/full

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