Guanabenz acetate, an antihypertensive drug repurposed as an inhibitor of Escherichia coli biofilm

ABSTRACT Biofilms formed by Escherichia coli are composed of amyloid curli and cellulose and have been shown to be linked to pathogenicity, antibiotic resistance, and chronic infections. Guanabenz acetate (GABE), an antihypertensive drug, was identified as a potential strategic repurposing drug due...

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Bibliographic Details
Main Authors: Arakkaveettil Kabeer Farha, Olivier Habimana, Harold Corke
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:Microbiology Spectrum
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00738-24