DMA, a Small Molecule, Increases Median Survival and Reduces Radiation-Induced Xerostomia via the Activation of the ERK1/2 Pathway in Oral Squamous Cell Carcinoma

DMA, a Small Molecule, Increases Median Survival and Reduces Radiation-Induced Xerostomia via the Activation of the ERK1/2 Pathway in Oral Squamous Cell Carcinoma

Survival, recurrence, and xerostomia are considerable problems in the treatment of oral squamous carcinoma patients. In this study, we investigated the role of DMA (5-(4-methylpiperazin-1-yl)-2-[2′-(3,4-dimethoxyphenyl)5″benzimidazoyl]benzimidazole) as a salivary gland cytoprotectant in a patient-de...

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Bibliographic Details
Main Authors: Palak Parashar, Monoj Kumar Das, Pragya Tripathi, Tejinder Kataria, Deepak Gupta, Deepak Sarin, Puja Panwar Hazari, Vibha Tandon
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Cancers
Subjects:
head and neck
patient-derived xenograft
salivary gland cytoprotectant
xerostomia
Online Access:https://www.mdpi.com/2072-6694/14/19/4908

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https://www.mdpi.com/2072-6694/14/19/4908

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