Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma

Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma

Abstract Epithelial ovarian cancer (EOC) is a leading cause of cancer-related mortality in the United States due to the late-stage disease at diagnosis. Overexpression of GRP78 and PDI following endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) promote growth an...

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Main Authors: Soma Samanta, Shuzo Tamura, Louis Dubeau, Paulette Mhawech-Fauceglia, Yohei Miyagi, Hisamori Kato, Rich Lieberman, Ronald J. Buckanovich, Yvonne G. Lin, Nouri Neamati
Format: Article
Language:English
Published: Nature Portfolio 2020-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-59116-x

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https://doi.org/10.1038/s41598-020-59116-x

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