Genetic Modification of Cytokine Signaling to Enhance Efficacy of CAR T Cell Therapy in Solid Tumors

Genetic Modification of Cytokine Signaling to Enhance Efficacy of CAR T Cell Therapy in Solid Tumors

Chimeric antigen receptor (CAR) T cell therapy has shown unprecedented success in treating advanced hematological malignancies. Its effectiveness in solid tumors has been limited due to heterogeneous antigen expression, a suppressive tumor microenvironment, suboptimal trafficking to the tumor site a...

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Bibliographic Details
Main Authors: Navid Ghahri-Saremi, Behnia Akbari, Tahereh Soltantoyeh, Jamshid Hadjati, Saba Ghassemi, Hamid Reza Mirzaei
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Immunology
Subjects:
cytokines
chemokines
genetic modification
CAR T cell
immunotherapy
solid tumors
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.738456/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.738456/full

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