Human umbilical cord mesenchymal stem cell exosome-derived miR-874-3p targeting RIPK1/PGAM5 attenuates kidney tubular epithelial cell damage

Human umbilical cord mesenchymal stem cell exosome-derived miR-874-3p targeting RIPK1/PGAM5 attenuates kidney tubular epithelial cell damage

Abstract Background Kidney insults due to various pathogenic factors, such as trauma, infection, and inflammation, can cause tubular epithelial cell injury and death, leading to acute kidney injury and the transformation of acute kidney injury to chronic kidney disease. There is no definitive treatm...

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Bibliographic Details
Main Authors: Yihang Yu, Meiling Chen, Qitong Guo, Lianju Shen, Xing Liu, Jianbo Pan, Yuanyuan Zhang, Tao Xu, Deying Zhang, Guanghui Wei
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Cellular & Molecular Biology Letters
Subjects:
Human umbilical cord mesenchymal stem cells
Exosome
Necroptosis
Mitochondrial fusion
miR-874-3p
Kidney tubular epithelial cell damage
Online Access:https://doi.org/10.1186/s11658-023-00425-0

Internet

https://doi.org/10.1186/s11658-023-00425-0

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