The EP300, KDM5A, KDM6A and KDM6B chromatin regulators cooperate with KLF4 in the transcriptional activation of POU5F1.

The EP300, KDM5A, KDM6A and KDM6B chromatin regulators cooperate with KLF4 in the transcriptional activation of POU5F1.

POU5F1 is essential for maintaining pluripotency in embryonic stem cells (ESCs). It has been reported that the constitutive activation of POU5F1 is sustained by the core transcriptional regulatory circuitry in ESCs; however, the means by which POU5F1 is epigenetically regulated remains enigmatic. In...

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Bibliographic Details
Main Authors: Wan-Ping Wang, Tsai-Yu Tzeng, Jing-Ya Wang, Don-Ching Lee, Yu-Hsiang Lin, Pei-Chun Wu, Yen-Po Chen, Ing-Ming Chiu, Ya-Hui Chi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3525641?pdf=render

Internet

http://europepmc.org/articles/PMC3525641?pdf=render

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