Dynamic silencing of somatic L1 retrotransposon insertions reflects the developmental and cellular contexts of their genomic integration

Dynamic silencing of somatic L1 retrotransposon insertions reflects the developmental and cellular contexts of their genomic integration

Abstract Background The ongoing mobilization of mammalian transposable elements (TEs) contributes to natural genetic variation. To survey the epigenetic control and expression of reporter genes inserted by L1 retrotransposition in diverse cellular and genomic contexts, we engineered highly sensitive...

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Bibliographic Details
Main Authors: Manoj Kannan, Jingfeng Li, Sarah E. Fritz, Kathryn E. Husarek, Jonathan C. Sanford, Teresa L. Sullivan, Pawan Kumar Tiwary, Wenfeng An, Jef D. Boeke, David E. Symer
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Mobile DNA
Subjects:
Cytosine Methylation
Reporter Expression
Culture Cancer Cell
Embryonic Stem Cell Clone
Artificial Intron
Online Access:http://link.springer.com/article/10.1186/s13100-017-0091-2

Internet

http://link.springer.com/article/10.1186/s13100-017-0091-2

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