BRD9 Inhibition by Natural Polyphenols Targets DNA Damage/Repair and Apoptosis in Human Colon Cancer Cells

BRD9 Inhibition by Natural Polyphenols Targets DNA Damage/Repair and Apoptosis in Human Colon Cancer Cells

Epigenetic mechanisms play an important role in the etiology of colorectal cancer (CRC) and other malignancies due, in part, to deregulated bromodomain (BRD) functions. Inhibitors of the bromodomain and extraterminal (BET) family have entered into clinical trials as anticancer agents, and interest h...

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Bibliographic Details
Main Authors: Sabeeta Kapoor, Elisabetta Damiani, Shan Wang, Ravirajan Dharmanand, Chakrapani Tripathi, Jorge Enrique Tovar Perez, Wan Mohaiza Dashwood, Praveen Rajendran, Roderick Hugh Dashwood
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Nutrients
Subjects:
apoptosis
bromodomain inhibition
colorectal cancer
molecular docking
Online Access:https://www.mdpi.com/2072-6643/14/20/4317

Internet

https://www.mdpi.com/2072-6643/14/20/4317

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