Anticancer Agents Targeted to Sirtuins
Sirtuins are nicotinamide adenine dinucleotide+-dependent deacetylases of which there are seven isoforms (SIRT1–7). Sirtuin activity is linked to gene expression, lifespan extension, neurodegeneration, and age-related disorders. Numerous studies have suggested that sirtuins could be of great signifi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-12-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/12/20295 |
| _version_ | 1819111329329315840 |
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| author | Tomohiro Kozako Takayoshi Suzuki Makoto Yoshimitsu Naomichi Arima Shin-ichiro Honda Shinji Soeda |
| author_facet | Tomohiro Kozako Takayoshi Suzuki Makoto Yoshimitsu Naomichi Arima Shin-ichiro Honda Shinji Soeda |
| author_sort | Tomohiro Kozako |
| collection | DOAJ |
| description | Sirtuins are nicotinamide adenine dinucleotide+-dependent deacetylases of which there are seven isoforms (SIRT1–7). Sirtuin activity is linked to gene expression, lifespan extension, neurodegeneration, and age-related disorders. Numerous studies have suggested that sirtuins could be of great significance with regard to both antiaging and tumorigenesis, depending on its targets in specific signaling pathways or in specific cancers. Recent studies have identified small chemical compounds that modulate sirtuins, and these modulators have enabled a greater understanding of the biological function and molecular mechanisms of sirtuins. This review highlights the possibility of sirtuins, especially SIRT1 and SIRT2, for cancer therapy targets, and focuses on the therapeutic potential of sirtuin modulators both in cancer prevention and treatment. |
| first_indexed | 2024-12-22T03:55:53Z |
| format | Article |
| id | doaj.art-dd6bd9367c58441caced04510d0db9ec |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-22T03:55:53Z |
| publishDate | 2014-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-dd6bd9367c58441caced04510d0db9ec2022-12-21T18:39:52ZengMDPI AGMolecules1420-30492014-12-011912202952031310.3390/molecules191220295molecules191220295Anticancer Agents Targeted to SirtuinsTomohiro Kozako0Takayoshi Suzuki1Makoto Yoshimitsu2Naomichi Arima3Shin-ichiro Honda4Shinji Soeda5Department of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JapanFaculty of Medicine, Kyoto Prefectural University of Medicine, 1-5 Shimogamohangi-Cho, Sakyo-Ku, Kyoto 606-0823, JapanDepartment of Hematology and Immunology, Kagoshima University Hospital, Kagoshima, 8-35-1 Sakuragaoka, Kagoshima 890-8544, JapanDepartment of Hematology and Immunology, Kagoshima University Hospital, Kagoshima, 8-35-1 Sakuragaoka, Kagoshima 890-8544, JapanDepartment of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JapanDepartment of Biochemistry, Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, JapanSirtuins are nicotinamide adenine dinucleotide+-dependent deacetylases of which there are seven isoforms (SIRT1–7). Sirtuin activity is linked to gene expression, lifespan extension, neurodegeneration, and age-related disorders. Numerous studies have suggested that sirtuins could be of great significance with regard to both antiaging and tumorigenesis, depending on its targets in specific signaling pathways or in specific cancers. Recent studies have identified small chemical compounds that modulate sirtuins, and these modulators have enabled a greater understanding of the biological function and molecular mechanisms of sirtuins. This review highlights the possibility of sirtuins, especially SIRT1 and SIRT2, for cancer therapy targets, and focuses on the therapeutic potential of sirtuin modulators both in cancer prevention and treatment.http://www.mdpi.com/1420-3049/19/12/20295sirtuinscancerapoptosisautophagy |
| spellingShingle | Tomohiro Kozako Takayoshi Suzuki Makoto Yoshimitsu Naomichi Arima Shin-ichiro Honda Shinji Soeda Anticancer Agents Targeted to Sirtuins Molecules sirtuins cancer apoptosis autophagy |
| title | Anticancer Agents Targeted to Sirtuins |
| title_full | Anticancer Agents Targeted to Sirtuins |
| title_fullStr | Anticancer Agents Targeted to Sirtuins |
| title_full_unstemmed | Anticancer Agents Targeted to Sirtuins |
| title_short | Anticancer Agents Targeted to Sirtuins |
| title_sort | anticancer agents targeted to sirtuins |
| topic | sirtuins cancer apoptosis autophagy |
| url | http://www.mdpi.com/1420-3049/19/12/20295 |
| work_keys_str_mv | AT tomohirokozako anticanceragentstargetedtosirtuins AT takayoshisuzuki anticanceragentstargetedtosirtuins AT makotoyoshimitsu anticanceragentstargetedtosirtuins AT naomichiarima anticanceragentstargetedtosirtuins AT shinichirohonda anticanceragentstargetedtosirtuins AT shinjisoeda anticanceragentstargetedtosirtuins |