Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin

Abstract Mutations in the G protein-coupled receptor (GPCR) rhodopsin are a common cause of autosomal dominant retinitis pigmentosa, a blinding disease. Rhodopsin self-associates in the membrane, and the purified monomeric apo-protein opsin dimerizes in vitro as it transitions from detergent micelle...

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Bibliographic Details
Main Authors: George Khelashvili, Anoop Narayana Pillai, Joon Lee, Kalpana Pandey, Alexander M. Payne, Zarek Siegel, Michel A. Cuendet, Tylor R. Lewis, Vadim Y. Arshavsky, Johannes Broichhagen, Joshua Levitz, Anant K. Menon
Format: Article
Language:English
Published: Nature Portfolio 2021-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-90039-3

Internet

https://doi.org/10.1038/s41598-021-90039-3

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