The emerging roles of sphingosine 1-phosphate and SphK1 in cancer resistance: a promising therapeutic target

The emerging roles of sphingosine 1-phosphate and SphK1 in cancer resistance: a promising therapeutic target

Abstract Cancer chemoresistance is a problematic dilemma that significantly restrains numerous cancer management protocols. It can promote cancer recurrence, spreading of cancer, and finally, mortality. Accordingly, enhancing the responsiveness of cancer cells towards chemotherapies could be a vital...

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Bibliographic Details
Main Authors: Samar Sami Alkafaas, Mohamed I. Elsalahaty, Doha F. Ismail, Mustafa Ali Radwan, Sara Samy Elkafas, Samah A. Loutfy, Rami M. Elshazli, Narjes Baazaoui, Ahmed Ezzat Ahmed, Wael Hafez, Mohanad Diab, Mohamed Sakran, Mohamed T. El-Saadony, Khaled A. El-Tarabily, Hani K. Kamal, Mohamed Hessien
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Cancer Cell International
Subjects:
Cancer
Recurrence
Chemoresistance
S1P
SphK1
TME
Online Access:https://doi.org/10.1186/s12935-024-03221-8

Internet

https://doi.org/10.1186/s12935-024-03221-8

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