Polymorphism of MMP-3 gene and imbalance expression of MMP-3 / TIMP-1 in articular cartilage are associated with an endemic osteochondropathy, Kashin- Beck disease

Polymorphism of MMP-3 gene and imbalance expression of MMP-3 / TIMP-1 in articular cartilage are associated with an endemic osteochondropathy, Kashin- Beck disease

Abstract Background The etiology of Kashin-Beck disease (KBD), an endemic osteochondropathy, is largely unknown. Matrix metalloproteinase-3 (MMP-3) plays a central role in the initiation and progression of cartilage destruction, however, no study has reported on the relationship between KBD and MMP-...

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Bibliographic Details
Main Authors: Bohui Shi, Xiong Guo, Aili Iv, Zengtie Zhang, Xiaowei Shi
Format: Article
Language:English
Published: BMC 2022-01-01
Series:BMC Musculoskeletal Disorders
Subjects:
Kashin-Beck disease
Matrix metalloproteinase-3
Tissue inhibitors of matrixmetalloproteinases-1
Single nucleotide polymorphisms
Immunohistochemistry
Online Access:https://doi.org/10.1186/s12891-021-04952-9

Internet

https://doi.org/10.1186/s12891-021-04952-9

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