mRNA-based precision targeting of neoantigens and tumor-associated antigens in malignant brain tumors

mRNA-based precision targeting of neoantigens and tumor-associated antigens in malignant brain tumors

Abstract Background Despite advancements in the successful use of immunotherapy in treating a variety of solid tumors, applications in treating brain tumors have lagged considerably. This is due, at least in part, to the lack of well-characterized antigens expressed within brain tumors that can medi...

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Bibliographic Details
Main Authors: Vrunda Trivedi, Changlin Yang, Kelena Klippel, Oleg Yegorov, Christina von Roemeling, Lan Hoang-Minh, Graeme Fenton, Elizabeth Ogando-Rivas, Paul Castillo, Ginger Moore, Kaytora Long-James, Kyle Dyson, Bently Doonan, Catherine Flores, Duane A. Mitchell
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Genome Medicine
Subjects:
Personalized immunotherapy
Cancer immunity
mRNA therapeutics
Vaccines
Adoptive T cell therapy
Immune checkpoint blockade
Online Access:https://doi.org/10.1186/s13073-024-01281-z

Internet

https://doi.org/10.1186/s13073-024-01281-z

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