Myeloid liver kinase B1 contributes to lung inflammation induced by lipoteichoic acid but not by viable Streptococcus pneumoniae

Myeloid liver kinase B1 contributes to lung inflammation induced by lipoteichoic acid but not by viable Streptococcus pneumoniae

Abstract Background Liver kinase B1 (Lkb1, gene name Stk11) functions as a tumor suppressor in cancer. Myeloid cell Lkb1 potentiates lung inflammation induced by the Gram-negative bacterial cell wall component lipopolysaccharide and in host defense during Gram-negative pneumonia. Here, we sought to...

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Bibliographic Details
Main Authors: Liza Pereverzeva, Natasja A. Otto, Joris J. T. H. Roelofs, Alex F. de Vos, Tom van der Poll
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Respiratory Research
Subjects:
Liver kinase B1
Streptococcus pneumoniae
Lipoteichoic acid
Pneumonia
Alveolar macrophages
Online Access:https://doi.org/10.1186/s12931-022-02168-6

Internet

https://doi.org/10.1186/s12931-022-02168-6

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