Potential factors contributing to the poor antimicrobial efficacy of SAAP-148 in a rat wound infection model

Potential factors contributing to the poor antimicrobial efficacy of SAAP-148 in a rat wound infection model

Abstract Background We investigated the efficacy of a synthetic antimicrobial peptide SAAP-148, which was shown to be effective against Methicillin-resistant Staphylococcus aureus (MRSA) on tape-stripped mice skin. Unexpectedly, SAAP-148 was not effective against MRSA in our pilot study using rats w...

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Bibliographic Details
Main Authors: Gabrielle S. Dijksteel, Magda M. W. Ulrich, Marcel Vlig, Peter H. Nibbering, Robert A. Cordfunke, Jan W. Drijfhout, Esther Middelkoop, Bouke K. H. L. Boekema
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Annals of Clinical Microbiology and Antimicrobials
Subjects:
Antimicrobial peptides
SAAP-148
Efficacy
Topical therapy
Skin and soft tissue infections
Methicillin-resistant Staphylococcus aureus
Online Access:https://doi.org/10.1186/s12941-019-0336-7

Internet

https://doi.org/10.1186/s12941-019-0336-7

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