A widespread single amino acid mutation in AcrA reduces tigecycline susceptibility in Klebsiella pneumoniae
ABSTRACT Whole-genome sequencing of a clinical tigecycline non-susceptible Klebsiella pneumoniae strain reveals a novel T188A mutation in AcrA, raising awareness on its role in tigecycline resistance. Through structural analysis of AcrAB-TolC in Escherichia coli that is highly homologous to K. pneum...
| প্রধান লেখক: | , , , , , , |
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| বিন্যাস: | প্রবন্ধ |
| ভাষা: | English |
| প্রকাশিত: |
American Society for Microbiology
2024-01-01
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| মালা: | Microbiology Spectrum |
| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://journals.asm.org/doi/10.1128/spectrum.02030-23 |