A widespread single amino acid mutation in AcrA reduces tigecycline susceptibility in Klebsiella pneumoniae
ABSTRACT Whole-genome sequencing of a clinical tigecycline non-susceptible Klebsiella pneumoniae strain reveals a novel T188A mutation in AcrA, raising awareness on its role in tigecycline resistance. Through structural analysis of AcrAB-TolC in Escherichia coli that is highly homologous to K. pneum...
| Main Authors: | , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
| 出版: |
American Society for Microbiology
2024-01-01
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| 丛编: | Microbiology Spectrum |
| 主题: | |
| 在线阅读: | https://journals.asm.org/doi/10.1128/spectrum.02030-23 |