Physicochemical stability of compounded midazolam capsules over a one-year storage period
In patients suffering from chronic liver disease, the hepatic metabolism of drugs is perturbed and the metabolic capacity is difficult to assess. Midazolam could be used as a phenotypical probe to predict the metabolic capacity of CYP3A to adjust dosages of drug substrates of this cytochrome. In thi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2020-05-01
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| Series: | Pharmaceutical Technology in Hospital Pharmacy |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/pthp-2020-0015 |
| _version_ | 1819124213043167232 |
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| author | Boivin Pierre-Nicolas Legendre Pauline Bonnaure Anne-Claire Lester Marie-Antoinette |
| author_facet | Boivin Pierre-Nicolas Legendre Pauline Bonnaure Anne-Claire Lester Marie-Antoinette |
| author_sort | Boivin Pierre-Nicolas |
| collection | DOAJ |
| description | In patients suffering from chronic liver disease, the hepatic metabolism of drugs is perturbed and the metabolic capacity is difficult to assess. Midazolam could be used as a phenotypical probe to predict the metabolic capacity of CYP3A to adjust dosages of drug substrates of this cytochrome. In this context, a prospective clinical trial is going to be conducted in our institution and a hospital preparation of midazolam capsules suitable for the clinical trial was developed. The objective of the present work was to assess the physicochemical stability of the formulation over 12 months to set shelf life. |
| first_indexed | 2024-12-22T07:20:40Z |
| format | Article |
| id | doaj.art-dd812719b93a4f43a38aa6b85c439810 |
| institution | Directory Open Access Journal |
| issn | 2365-2411 2365-242X |
| language | English |
| last_indexed | 2024-12-22T07:20:40Z |
| publishDate | 2020-05-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Pharmaceutical Technology in Hospital Pharmacy |
| spelling | doaj.art-dd812719b93a4f43a38aa6b85c4398102022-12-21T18:34:16ZengDe GruyterPharmaceutical Technology in Hospital Pharmacy2365-24112365-242X2020-05-015115657310.1515/pthp-2020-0015pthp-2020-0015Physicochemical stability of compounded midazolam capsules over a one-year storage periodBoivin Pierre-Nicolas0Legendre Pauline1Bonnaure Anne-Claire2Lester Marie-Antoinette3Pharmacy Department, Pharmaceutical Technology Unit, Rennes University Hospital, Rennes, FrancePharmacy Department, Pharmaceutical Technology Unit, Rennes University Hospital, Rennes, FrancePharmacy Department, Pharmaceutical Technology Unit, Rennes University Hospital, Rennes, FrancePharmacy Department, Pharmaceutical Technology Unit, Rennes University Hospital, Rennes, FranceIn patients suffering from chronic liver disease, the hepatic metabolism of drugs is perturbed and the metabolic capacity is difficult to assess. Midazolam could be used as a phenotypical probe to predict the metabolic capacity of CYP3A to adjust dosages of drug substrates of this cytochrome. In this context, a prospective clinical trial is going to be conducted in our institution and a hospital preparation of midazolam capsules suitable for the clinical trial was developed. The objective of the present work was to assess the physicochemical stability of the formulation over 12 months to set shelf life.https://doi.org/10.1515/pthp-2020-0015cyp3ahepatic failuremidazolam capsulespersonalized medicinephenotypic probe |
| spellingShingle | Boivin Pierre-Nicolas Legendre Pauline Bonnaure Anne-Claire Lester Marie-Antoinette Physicochemical stability of compounded midazolam capsules over a one-year storage period Pharmaceutical Technology in Hospital Pharmacy cyp3a hepatic failure midazolam capsules personalized medicine phenotypic probe |
| title | Physicochemical stability of compounded midazolam capsules over a one-year storage period |
| title_full | Physicochemical stability of compounded midazolam capsules over a one-year storage period |
| title_fullStr | Physicochemical stability of compounded midazolam capsules over a one-year storage period |
| title_full_unstemmed | Physicochemical stability of compounded midazolam capsules over a one-year storage period |
| title_short | Physicochemical stability of compounded midazolam capsules over a one-year storage period |
| title_sort | physicochemical stability of compounded midazolam capsules over a one year storage period |
| topic | cyp3a hepatic failure midazolam capsules personalized medicine phenotypic probe |
| url | https://doi.org/10.1515/pthp-2020-0015 |
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