A Standardized Botanical Composition Mitigated Acute Inflammatory Lung Injury and Reduced Mortality through Extracellular HMGB1 Reduction

A Standardized Botanical Composition Mitigated Acute Inflammatory Lung Injury and Reduced Mortality through Extracellular HMGB1 Reduction

HMGB1 is a key late inflammatory mediator upregulated during air-pollution-induced oxidative stress. Extracellular HMGB1 accumulation in the airways and lungs plays a significant role in the pathogenesis of inflammatory lung injury. Decreasing extracellular HMBG1 levels may restore innate immune cel...

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Bibliographic Details
Main Authors: Mesfin Yimam, Teresa Horm, Alexandria O’Neal, Ping Jiao, Mei Hong, Lidia Brownell, Qi Jia, Mosi Lin, Alex Gauthier, Jiaqi Wu, Kranti Venkat Mateti, Xiaojian Yang, Katelyn Dial, Sidorela Zefi, Lin L. Mantell
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Molecules
Subjects:
HMGB1
inflammatory lung injury
oxidative stress
sepsis
Online Access:https://www.mdpi.com/1420-3049/28/18/6560

Internet

https://www.mdpi.com/1420-3049/28/18/6560

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