Hypoxia drives shared and distinct transcriptomic changes in two invasive glioma stem cell lines

Hypoxia drives shared and distinct transcriptomic changes in two invasive glioma stem cell lines

Abstract Glioblastoma (GBM) is the most common primary malignant cancer of the central nervous system. Insufficient oxygenation (hypoxia) has been linked to GBM invasion and aggression, leading to poor patient outcomes. Hypoxia induces gene expression for cellular adaptations. However, GBM is charac...

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Bibliographic Details
Main Authors: Valerie J. Marallano, Mary E. Ughetta, Rut Tejero, Sidhanta Nanda, Rohana Ramalingam, Lauren Stalbow, Anirudh Sattiraju, Yong Huang, Aarthi Ramakrishnan, Li Shen, Alexandre Wojcinski, Santosh Kesari, Hongyan Zou, Alexander M. Tsankov, Roland H. Friedel
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Subjects:
Glioblastoma
glioma
hypoxia
Online Access:https://doi.org/10.1038/s41598-024-56102-5

Internet

https://doi.org/10.1038/s41598-024-56102-5

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