Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

Mapping kinase domain resistance mechanisms for the MET receptor tyrosine kinase via deep mutational scanning

Mutations in the kinase and juxtamembrane domains of the MET Receptor Tyrosine Kinase are responsible for oncogenesis in various cancers and can drive resistance to MET-directed treatments. Determining the most effective inhibitor for each mutational profile is a major challenge for MET-driven cance...

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Bibliographic Details
Main Authors: Gabriella O Estevam, Edmond Linossi, Jingyou Rao, Christian B Macdonald, Ashraya Ravikumar, Karson M Chrispens, John A Capra, Willow Coyote-Maestas, Harold Pimentel, Eric A Collisson, Natalia Jura, James S Fraser
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-02-01
Series:eLife
Subjects:
protein kinase
mutagenesis
drug discovery
Online Access:https://elifesciences.org/articles/101882

Internet

https://elifesciences.org/articles/101882

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