Alcohol-Induced Lysosomal Damage and Suppression of Lysosome Biogenesis Contribute to Hepatotoxicity in HIV-Exposed Liver Cells

Alcohol-Induced Lysosomal Damage and Suppression of Lysosome Biogenesis Contribute to Hepatotoxicity in HIV-Exposed Liver Cells

Although the causes of hepatotoxicity among alcohol-abusing HIV patients are multifactorial, alcohol remains the least explored “second hit” for HIV-related hepatotoxicity. Here, we investigated whether metabolically derived acetaldehyde impairs lysosomes to enhance HIV-induced hepatotoxicity. We ex...

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Bibliographic Details
Main Authors: Moses New-Aaron, Paul G. Thomes, Murali Ganesan, Raghubendra Singh Dagur, Terrence M. Donohue, Kharbanda K. Kusum, Larisa Y. Poluektova, Natalia A. Osna
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Biomolecules
Subjects:
lysosome damage
lysosome biogenesis
HIV
ethanol metabolites
hepatotoxicity
Online Access:https://www.mdpi.com/2218-273X/11/10/1497

Internet

https://www.mdpi.com/2218-273X/11/10/1497

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