Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes.

Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes.

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Impaired glucose tolerance is a major risk factor for type 2 diabetes (T2D) and several cardiometabolic disorders. To identify genetic loci underlying fasting glucose levels, we conducted an analysis of 9,232 individuals of European ancestry who at enrollment were either nondiabetic or had untreated...

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Bibliographic Details
Main Authors: Guanjie Chen, Daniel Shriner, Jianhua Zhang, Jie Zhou, Poorni Adikaram, Ayo P Doumatey, Amy R Bentley, Adebowale Adeyemo, Charles N Rotimi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0269378

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https://doi.org/10.1371/journal.pone.0269378

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