Cardiomyocyte-Specific Loss of Glutamyl-prolyl-tRNA Synthetase Leads to Disturbed Protein Homeostasis and Dilated Cardiomyopathy

Cardiomyocyte-Specific Loss of Glutamyl-prolyl-tRNA Synthetase Leads to Disturbed Protein Homeostasis and Dilated Cardiomyopathy

Glutamyl-prolyl-tRNA synthetase (EPRS1), an aminoacyl-tRNA synthetase (ARS) ligating glutamic acid and proline to their corresponding tRNAs, plays an essential role in decoding proline codons during translation elongation. The physiological function of EPRS1 in cardiomyocytes (CMs) and the potential...

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Bibliographic Details
Main Authors: Jiangbin Wu, Jared Hollinger, Emily Bonanno, Feng Jiang, Peng Yao
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Cells
Subjects:
cardiomyocyte
cardiomyopathy
EPRS1
heart failure
translational control
Online Access:https://www.mdpi.com/2073-4409/13/1/35

Internet

https://www.mdpi.com/2073-4409/13/1/35

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