Rapid and Flexible RT-qPCR Surveillance Platforms To Detect SARS-CoV-2 Mutations

Rapid and Flexible RT-qPCR Surveillance Platforms To Detect SARS-CoV-2 Mutations

ABSTRACT Multiple mutations in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) increase transmission, disease severity, and immune evasion and facilitate zoonotic or anthropozoonotic infections. Four such mutations, ΔH69/V70, L452R, E484K, and N501Y, occurred...

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Bibliographic Details
Main Authors: Katja Spiess, Vithiagaran Gunalan, Ellinor Marving, Sofie Holdflod Nielsen, Michelle G. P. Jørgensen, Anna S. Fomsgaard, Line Nielsen, Alonzo Alfaro-Núñez, Søren M. Karst, Shila Mortensen, Morten Rasmussen, Ria Lassaunière, Maiken Worsøe Rosenstierne, Charlotta Polacek, Jannik Fonager, Arieh S. Cohen, Claus Nielsen, Anders Fomsgaard
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2
signature mutations
variant of concern
variant PCR
large-scale screening
whole-genome sequencing
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03591-22

Internet

https://journals.asm.org/doi/10.1128/spectrum.03591-22

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