A systematic review of the “promising zone” design

A systematic review of the “promising zone” design

Abstract Introduction Sample size calculations require assumptions regarding treatment response and variability. Incorrect assumptions can result in under- or overpowered trials, posing ethical concerns. Sample size re-estimation (SSR) methods investigate the validity of these assumptions and increa...

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Bibliographic Details
Main Authors: Julia M. Edwards, Stephen J. Walters, Cornelia Kunz, Steven A. Julious
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Trials
Subjects:
Promising zone
Unblinded sample size re-estimation
Systematic review
Sample size calculations
Online Access:https://doi.org/10.1186/s13063-020-04931-w

Internet

https://doi.org/10.1186/s13063-020-04931-w

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