The Role of NMDA Receptor Partial Antagonist, Carbamathione, as a Therapeutic Agent for Transient Global Ischemia

The Role of NMDA Receptor Partial Antagonist, Carbamathione, as a Therapeutic Agent for Transient Global Ischemia

Carbamathione (Carb), an NMDA glutamate receptor partial antagonist, has potent neuroprotective functions against hypoxia- or ischemia-induced neuronal injury in cell- or animal-based stroke models. We used PC-12 cell cultures as a cell-based model and bilateral carotid artery occlusion (BCAO) for s...

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Bibliographic Details
Main Authors: Jigar Pravinchandra Modi, Wen Shen, Janet Menzie-Suderam, Hongyuan Xu, Chun-Hua Lin, Rui Tao, Howard M. Prentice, John Schloss, Jang-Yen Wu
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Biomedicines
Subjects:
Carbamathione (Carb)
glutamate
hypoxia
endoplasmic reticulum (ER) stress
PC-12 cell culture
stroke
Online Access:https://www.mdpi.com/2227-9059/11/7/1885

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https://www.mdpi.com/2227-9059/11/7/1885

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