Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2

Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2

HAP2 is a transmembrane gamete fusogen found in multiple eukaryotic kingdoms and is structurally homologous to viral class II fusogens. Studies in Plasmodium have suggested that HAP2 is an attractive target for vaccines that block transmission of malaria. HAP2 has three extracellular domains, arrang...

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Bibliographic Details
Main Authors: Juan Feng, Xianchi Dong, Adam DeCosta, Yang Su, Fiona Angrisano, Katarzyna A Sala, Andrew M Blagborough, Chafen Lu, Timothy A Springer
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
HAP2
malaria transmission-blocking vaccine
membrane fusion
gamete fusogen
Online Access:https://elifesciences.org/articles/74707

Internet

https://elifesciences.org/articles/74707

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