Hepatitis C Virus-Infected Apoptotic Hepatocytes Program Macrophages and Hepatic Stellate Cells for Liver Inflammation and Fibrosis Development: Role of Ethanol as a Second Hit

Hepatitis C Virus-Infected Apoptotic Hepatocytes Program Macrophages and Hepatic Stellate Cells for Liver Inflammation and Fibrosis Development: Role of Ethanol as a Second Hit

Hepatocyte apoptosis is a crucially important mechanism for liver disease pathogenesis, and the engulfment of apoptotic bodies (AB) by non-parenchymal cells serves as a leading mechanism of inflammation and fibrosis progression. Previously, we have shown that hepatitis C virus (HCV) and alcohol meta...

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Bibliographic Details
Main Authors: Murali Ganesan, Larisa Y. Poluektova, Chijioke Enweluzo, Kusum K. Kharbanda, Natalia A. Osna
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Biomolecules
Subjects:
acetaldehyde
HCV
apoptotic bodies
liver inflammation
fibrosis
ethanol
Online Access:http://www.mdpi.com/2218-273X/8/4/113

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http://www.mdpi.com/2218-273X/8/4/113

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