Inhibiting anti-angiogenic VEGF165b activates a miR-17-20a-Calcipressin-3 pathway that revascularizes ischemic muscle in peripheral artery disease

Inhibiting anti-angiogenic VEGF165b activates a miR-17-20a-Calcipressin-3 pathway that revascularizes ischemic muscle in peripheral artery disease

Abstract Background VEGF165a increases the expression of the microRNA-17-92 cluster, promoting developmental, retinal, and tumor angiogenesis. We have previously shown that VEGF165b, an alternatively spliced anti-angiogenic VEGF-A isoform, inhibits the VEGFR-STAT3 pathway in ischemic endothelial cel...

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Bibliographic Details
Main Authors: Sonia Batan, Sivaraman Kuppuswamy, Madison Wood, Meghana Reddy, Brian Annex, Vijay Ganta
Format: Article
Language:English
Published: Nature Portfolio 2024-01-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-023-00431-5

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https://doi.org/10.1038/s43856-023-00431-5

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